tNGS Targeted Panels

BACKGROUND

Background

Built on TargetSeq® hybridization capture sequencing technology, we have developed pathogen identification panels covering 435 and 1,358 common microorganisms. These panels cover the vast majority of pathogens encountered in routine clinical testing and serve as an effective adjunct to diagnosis—providing valuable complementary evidence to conventional clinical methods.

Paired with a mature rapid hybridization capture workflow and an SE100 sequencing strategy, the solution can meet an ultra-fast turnaround time (TAT) of within 16 hours* from sample to report.

TECHNOLOGY

Targeted NGS for Clinical Precision

Our tNGS panels combine the speed of multiplex PCR with the power of next-generation sequencing for rapid, accurate pathogen identification

Rapid Results

Sample to result in as little as 6 hours for urgent clinical cases

High Multiplexing

Screen for hundreds of pathogens in a single reaction

High Sensitivity

Detect pathogens at low copy numbers with optimized primer design

AMR Detection

Simultaneous detection of key antimicrobial resistance genes

COMPREHENSIVE PANELS

Choose Your Coverage Level

From rapid screening to comprehensive profiling, we have the right panel for your needs

Standard Panel

Core Pathogen Detection

                            435
                            Pathogens
                        

                            99.5%
                            Sensitivity
                        

Common clinical pathogens
Major bacteria & viruses
Key resistance markers
Cost-effective screening
Rapid turnaround

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COMPREHENSIVE

Extended Panel

Maximum Coverage

                            1,358
                            Pathogens
                        

                            5000+
                            AMR Genes
                        

Comprehensive coverage
Rare & emerging pathogens
Extended AMR profiling
Research applications
Outbreak investigation

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SYNDROME-SPECIFIC

Targeted Clinical Panels

Focused panels designed for specific clinical syndromes and sample types

Respiratory Panel

80+ respiratory pathogens including influenza, RSV, SARS-CoV-2, and bacterial pneumonia agents

Gastrointestinal Panel

60+ GI pathogens including bacteria, viruses, and parasites causing acute gastroenteritis

CNS Panel

40+ meningitis and encephalitis pathogens for cerebrospinal fluid analysis

Bloodstream Infection

100+ sepsis-causing pathogens with comprehensive resistance gene coverage

STI Panel

Comprehensive sexually transmitted infection screening including common and rare pathogens

Joint & Tissue Panel

Prosthetic joint infections and soft tissue infections with biofilm-forming bacteria

COMPARISON

tNGS vs Traditional Methods

Feature	OmniCapture tNGS	Traditional Culture	Standard PCR
Pathogen Coverage	435/1,385 species	Limited by media	1-20 targets
Turnaround Time	6-24 hours	24-72+ hours	2-4 hours
AMR Detection	Genotypic (5000+ genes)	Phenotypic (slow)	Limited markers
Unculturable Pathogens	✓ Detected	✗ Not detected	✓ If targeted
Cost per Target	Very low	Low per isolate	High
Throughput	96 samples/run	Variable	96 samples/run

SPECIFICATIONS

Technical Details

Sample Input

10-100 ng extracted nucleic acid or direct from sample

Protocol

Single-tube multiplex PCR with UMI tagging for accuracy

Read Depth

100K-1M reads per sample recommended

Platforms

Illumina MiSeq, NextSeq, NovaSeq and MGI platforms

Analysis

Cloud-based automated analysis with clinical reporting

Automation

Compatible with IGT automation workstations