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Digestive Tract Related Pathogens Panel

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BACKGROUND

Understanding Digestive Tract Related Pathogens

Gastrointestinal pathogens are microorganisms that can invade and colonize the human gastrointestinal tract (including the stomach, small intestine, and large intestine). They cause disease by damaging the mucosa, secreting toxins, or triggering inflammatory responses, leading to gastrointestinal dysfunction and illnesses such as diarrhea, vomiting, gastritis, and enteritis. These pathogens are primarily transmitted via the fecal–oral route, commonly through contaminated food or water or by direct person-to-person contact. Major categories of gastrointestinal pathogens include viruses, bacteria, parasites, and fungi.

iGeneTech's TargetSeq® liquid-phase probe hybridization capture technology, developed under independent intellectual property rights, together with its proprietary microbial probe design, is dedicated to addressing critical challenges such as viral variant surveillance, detection of low-abundance viral samples, and host-source tracing. We have released multiple full-genome detection kits for gastrointestinal pathogens.

PRODUCT LIST

Comprehensive Digestive Pathogen Detection Panels

Complete portfolio of targeted panels for specific digestive pathogens.

Product Name English Name Abbreviation Taxonomy ID Reference Genome Size Reference Sequence Number Number Of Probe
Norovirus Panel Norovirus GI NV-GI 122928 7.7 kb 6569 73161
Norovirus GII NV-GII 122929 7.6 kb
Norovirus GIII NV-GIII 340017 7.6 kb
Norovirus GIV NV-GIV 262897 7.9 kb
Norovirus GV NV-GV 1246677 7.4 kb
Norovirus isolates / 150080 7.6 kb
Rotavirus Panel Rotavirus A RV-A 28875 18.6 kb 1109 48809
Rotavirus B RV-B 28876 17.5 kb 811
Rotavirus C RV-C 36427 17.9 kb 1831
Enterovirus Panel Enterovirus A EV-A 138948 7.4 kb 2763 143791
Enterovirus B EV-B 138949 7.4 kb 866
Enterovirus C EV-C 138950 7.4 kb 1562
Enterovirus D EV-D 138951 7.4 kb 915
Enterovirus A71 EV-A71 39054 7.4 kb 1235
Enterovirus D68 EV-D68 42789 7.4 kb 862
Vibrio Cholerae Panel Vibrio cholerae V. cholerae 666 4.1 Mb 144 322030
Salmonella Panel Salmonella Sal 590 5.0 Mb 6180 903318
Campylobacter Coli Panel Campylobacter coli C. coli 195 1.6 Mb 168 179455
Yersinia Enterocolitica Panel Yersinia enterocolitica Y. enterocolitica 630 4.6 Mb 59 336263
Clostridioides Difficile Panel Clostridioides difficile C. diff 1496 4.2 Mb 258 464382
Campylobacter Jejuni Panel Campylobacter jejuni C. jejuni 197 1.6 Mb 508 139667
Clostridium Pasteurianum Panel Clostridium pasteurianum C. pasteurianum 1501 5.0 Mb 6 246463
Clostridium Butyricum Panel Clostridium butyricum C. butyricum 1492 4.7 Mb 21 195316
Vibrio Parahaemolyticus Panel Vibrio parahaemolyticus V. parahaemolyticus 670 4.8 Mb 221 552726
Human Astrovirus Panel Human astrovirus 1 HAstV-1 12456 6.8 kb 54 7281
Human astrovirus 2 HAstV-2 12701 6.8 kb 110
Human astrovirus 3 HAstV-3 35740 6.8 kb 123
Human astrovirus 4 HAstV-4 35300 6.8 kb 22
Human astrovirus 5 HAstV-5 35741 6.8 kb 117
Human astrovirus 6 HAstV-6 37130 6.8 kb 20
Human astrovirus 7 HAstV-7 38950 6.8 kb 8
Human astrovirus 8 HAstV-8 43358 6.8 kb 117
Human astrovirus HAstV 186658 6.8 kb 21
Sapovirus Panel Sapovirus SaV 55341 7.4 kb 184 16644
Vibrio Fluvialis Panel Vibrio fluvialis V. fluvialis 676 2.0 Mb 27 274968
Cronobacter Sakazakii Panel Cronobacter sakazakii C. sakazakii 28141 4.5 Mb 33 270147
Aeromonas Hydrophila Panel Aeromonas hydrophila A. hydrophila 644 4.7 Mb 101 574503
Diarrheagenic Escherichia Coli Panel Diarrheagenic Escherichia coli DEC 562 4.6 Mb 5 genomes 716523
Listeria Monocytogenes Panel Listeria monocytogenes L. monocytogenes 1639 2.9 Mb 607 254460
Bacteroides Fragilis Panel Bacteroides fragilis B. fragilis 817 5.2 Mb 83 562100
JC Virus x BK Virus Panel JC virus x BK virus JCV/BKV 178534 4.21 kb 3 63
Morganella Morganii Panel Morganella morganii M. morganii 582 3.9 Mb 99 388455
Bovine Rotavirus Panel Bovine rotavirus BRV 10927 8.9 kb 153 10222
Shigella Panel Shigella Shi 620 4.6 Mb 310 574629
PERFORMANCE

Performance — Measured Results

Measured capture results for representative digestive pathogens.

Norovirus testing results
Enterovirus testing results
ORDERING INFO

Catalog Numbers & Kit Sizes

Available kit sizes and iGeneTech catalog numbers.

Panel 16 rxn 96 rxn Order
Norovirus PanelPH2015831PH2015832
Rotavirus PanelPH2002361PH2002362
Enterovirus PanelPH2001871PH2001872
Vibrio Cholerae PanelPH2001441PH2001442
Salmonella PanelPH2009491PH2009492
Campylobacter Coli PanelPH2012101PH2012102
Yersinia Enterocolitica PanelPH2012111PH2012112
Clostridioides Difficile PanelPH2011671PH2011672
Campylobacter Jejuni PanelPH2011531PH2011532
Clostridium Pasteurianum PanelPH2010951PH2010952
Clostridium Butyricum PanelPH2010941PH2010942
Vibrio Parahaemolyticus PanelPH2011561PH2011562
Human Astrovirus PanelPH2009761PH2009762
Sapovirus PanelPH2006421PH2006422
Vibrio Fluvialis PanelPH2012161PH2012162
Cronobacter Sakazakii PanelPH2012121PH2012122
Aeromonas Hydrophila PanelPH2012141PH2012142
Diarrheagenic Escherichia Coli PanelPH2012081PH2012082
Listeria Monocytogenes PanelPH2012981PH2012982
Bacteroides Fragilis PanelPH2013041PH2013042
JC Virus x BK Virus PanelPH2014291PH2014292
Morganella Morganii PanelPH2013141PH2013142
Bovine Rotavirus PanelPH2015781PH2015782
Shigella PanelPH2012091PH2012092
Aeromonas PanelPH2013281PH2013282
Peptostreptococcus PanelPH2014351PH2014352
PANEL OVERVIEW

Comprehensive Gastrointestinal Pathogen Detection

The Digestive Tract Related Pathogens Panel enables simultaneous detection and identification of over 60 gastrointestinal pathogens from a single sample, covering bacteria, viruses, parasites, and fungi that cause enteric infections.

Full GI Tract Coverage

Detects pathogens causing gastroenteritis, gastritis, enterocolitis, hepatitis, and other digestive system infections

Multi-Pathogen Detection

Simultaneous detection of bacterial, viral, parasitic, and fungal pathogens in a single assay

Full-Genome Analysis

Complete genome capture enables strain typing and virulence factor detection

Rapid Diagnosis

Streamlined workflow delivers results within 24 hours for timely treatment decisions

KEY ADVANTAGES

Why Choose OmniCapture Digestive Panel

Advanced technology for gastrointestinal pathogen detection

Extensive Pathogen List

Detects over 60 GI pathogens including bacteria, viruses, parasites, and fungi

Full-Genome Analysis

Complete genome sequencing enables strain typing and resistance detection

High Sensitivity

Detects low-level pathogens with superior enrichment efficiency

Co-Infection Detection

Identifies multiple pathogens including mixed infections

Automated Workflow

Compatible with automated platforms for consistent high-throughput testing

Quality Assured

Validated performance meeting clinical testing standards

REFERENCES

Selected References

References cited on the original iGeneTech page (translated).

  1. Yu F, Ma N, Zhang X, et al. Comprehensive investigating of cytokine and receptor related genes variants in patients with chronic hepatitis B virus infection. Cytokine. 2018 Mar;103:10-14.
  2. Pang X, Ren L, et al. Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing. Natl Sci Rev. 2020 Oct 23;7(12):1861-1864.
  3. Du P, Ding N, et al. Genomic surveillance of COVID-19 cases in Beijing. Nat Commun. 2020 Oct 30;11(1):5503.
  4. Chen C, Li J, et al. MINERVA: A Facile Strategy for SARS-CoV-2 Whole-Genome Deep Sequencing of Clinical Samples. Mol Cell. 2020 Dec 17;80(6):1123-1134.e4.
  5. Xu Y, Kang L, et al. Dynamics of severe acute respiratory syndrome coronavirus 2 genome variants in the feces during convalescence. J Genet Genomics. 2020 Oct 20;47(10):610-617.
  6. Wu X, Ning C, et al. A 3,000-year-old, basal S. enterica lineage from Bronze Age Xinjiang suggests spread along the Proto-Silk Road. PLoS Pathog. 2021 Sep 21;17(9):e1009886.
  7. Zhang J, Ding N, et al. Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak. Innovation (Camb). 2021 May 28;2(2):100099.
  8. Li J, Du P, et al. Two-step fitness selection for intra-host variations in SARS-CoV-2. Cell Rep. 2022 Jan 11;38(2):110205.
  9. Song S, Li C, et al. Genomic Epidemiology of SARS-CoV-2 in Pakistan. Genomics Proteomics Bioinformatics. 2021 Oct;19(5):727-740.
  10. Zhang J, Tian X, et al. Feasibility and Accuracy of Menstrual Blood Testing for High-risk Human Papillomavirus Detection With Capture Sequencing. JAMA Netw Open. 2021 Dec 1;4(12):e2140644.
  11. Li P, Ke Y, et al. Targeted screening of genetic associations with COVID-19 susceptibility and severity. Front Genet. 2022 Nov 30;13:1073880.
  12. Pu R, Liu W, et al. The Effects and Underlying Mechanisms of Hepatitis B Virus X Gene Mutants on the Development of Hepatocellular Carcinoma. Front Oncol. 2022 Feb 10;12:836517.
  13. Zhang M, Zhang H, et al. Liver biopsy of chronic hepatitis B patients indicates HBV integration profile may complicate the endpoint and effect of entecavir treatment. Antiviral Res. 2022 Aug;204:105363.
  14. Shen C, Li Y, et al. HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation. Nat Commun. 2022 Nov 30;13(1):7368.
  15. Liu W, Cai S, et al. HBV preS Mutations Promote Hepatocarcinogenesis by Inducing Endoplasmic Reticulum Stress and Upregulating Inflammatory Signaling. Cancers (Basel). 2022 Jul 4;14(13):3274.
  16. Wang Y, Nan X, et al. Consumption of Supplementary Inulin Modulates Milk Microbiota and Metabolites in Dairy Cows with Subclinical Mastitis. Appl Environ Microbiol. 2022 Feb 22;88(4):e0205921.
  17. Lang B, Cao C, et al. Genomic alterations related to HPV infection status in a cohort of Chinese prostate cancer patients. Eur J Med Res. 2023 Jul 17;28(1):239.
  18. Adeola AC, Luka PD, et al. Target capture sequencing for the first Nigerian genotype I ASFV genome. Microb Genom. 2023 Jul;9(7):mgen001069.
  19. Sun B, Andrades Valtueña A, et al. Origin and dispersal history of Hepatitis B virus in Eastern Eurasia. Nat Commun. 2024 Apr 5;15(1):2951.
  20. Wang Z, Liu C, et al. Long-read sequencing reveals the structural complexity of genomic integration of HPV DNA in cervical cancer cell lines. BMC Genomics. 2024 Feb 20;25(1):198.
  21. Yang Z, Zeng J, et al. Detection of HBV DNA integration in plasma cell-free DNA of different HBV diseases utilizing DNA capture strategy. Virol Sin. 2024 Aug;39(4):655-666.

Ready to Enhance Your GI Pathogen Testing?

Contact our team to learn more about the Digestive Tract Related Pathogens Panel and how it can benefit your laboratory or research facility.

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