Respiratory Tract Related Pathogens Panel

BACKGROUND

Understanding Respiratory Pathogens

Respiratory pathogens are microorganisms that can invade and colonize the human respiratory system (including upper and lower respiratory tract) and cause infectious diseases. They are typically transmitted through droplets, aerosols, or contact, leading to a variety of clinical manifestations ranging from mild throat discomfort to severe pneumonia.

In community-acquired upper respiratory tract infections (such as common cold and pharyngitis), viruses are the most common causative agents. In community-acquired pneumonia (CAP), bacteria (especially Streptococcus pneumoniae, Haemophilus influenzae, and Mycoplasma) predominate. For immunocompromised individuals, attention must also be paid to fungal infections (P. jirovecii, Aspergillus) and drug-resistant mycobacterial infections.

iGeneTech, leveraging proprietary TargetSeq® liquid-phase probe hybridization capture technology and unique microbial probe design schemes, is committed to solving important challenges including viral variant monitoring, low-abundance virus sample detection, and host traceability. We have developed multiple respiratory pathogen whole-genome detection kits.

PRODUCT LIST

Comprehensive Respiratory Pathogen Detection Panels

Complete portfolio of targeted panels for specific respiratory pathogens

Panel Name	Pathogen Target	Scientific Name	Accession Number	Genome Size	Database Count	Probe Count
Influenza A/B/C Virus Panel	Influenza A virus	Influenza A virus	11320	13.5 kb	1250451	33609
	Influenza B virus	Influenza B virus	11520	13.3 kb
	Influenza C virus	Influenza C virus	11552	12.1 kb
SARS-CoV-2 Panel	COVID-19	Severe acute respiratory syndrome coronavirus 2	2697049	29.9 kb	3045955	11547
Pathogenic Coronavirus Panel	Human coronavirus 229E	Human coronavirus 229E	11137	27.3 kb	146	30476
	Human coronavirus HKU1	Human coronavirus HKU1	290028	29.9 kb
	Human coronavirus NL63	Human coronavirus NL63	277944	27.6 kb
	Human coronavirus OC43	Human coronavirus OC43	31631	30.7 kb
	Other pathogenic coronaviruses	MERS-CoV, SARS-CoV	1335626, 694009	30.1 kb
Human Respiratory Syncytial Virus Panel	RSV-A	Human respiratory syncytial virus A	208893	15.2 kb	3026	5391
Human Respiratory Syncytial Virus Panel	RSV-B	Human respiratory syncytial virus B	208895	15.3 kb	3026	5391
Human Metapneumovirus Panel	hMPV	Human metapneumovirus	162145	13.3 kb	413	6055
Human Parainfluenza Virus Panel	Parainfluenza 1	Human respirovirus 1	12730	15.6 kb	145	10477
	Parainfluenza 3	Human respirovirus 3	11216	15.5 kb
	Parainfluenza 2	Human orthorubulavirus 2	2560525	15.6 kb
	Parainfluenza 4	Human orthorubulavirus 4	2560526	17.4 kb
Human Mastadenovirus Panel	Adenovirus A	Human mastadenovirus A	129875	34.1 kb	145	57826
	Adenovirus B	Human mastadenovirus B	108098	35.3 kb
	Adenovirus C	Human mastadenovirus C	129951	35.9 kb
	Adenovirus D	Human mastadenovirus D	130310	35.1 kb
	Adenovirus E	Human mastadenovirus E	130308	36 kb
	Adenovirus F/G	Human mastadenovirus F/G	130309, 536079	34.2 kb
Rhinovirus Panel	Rhinovirus A	Rhinovirus A	147711	7.2 kb	902	113845
	Rhinovirus B	Rhinovirus B	147712	7.3 kb
	Rhinovirus C	Rhinovirus C	463676	7.1 kb
Varicella-Zoster Virus Panel	VZV	Human alphaherpesvirus 3/Varicella-zoster virus	10335	124.9 kb	162	15847
Mycoplasma Pneumoniae Panel	M. pneumoniae	Mycoplasma pneumoniae	2104	823 kb	81	22637
Chlamydia Psittaci Panel	C. psittaci	Chlamydia psittaci	83554	1.2 Mb	95	166256
Chlamydia Pneumoniae Panel	C. pneumoniae	Chlamydia pneumoniae	83558	1.2 Mb	14	42767
Chlamydia Trachomatis Panel	C. trachomatis	Chlamydia trachomatis	813	1 Mb	316	52810
Bordetella Pertussis Panel	B. pertussis	Bordetella pertussis	520	4.1 Mb	949	89635
Mycobacterium Tuberculosis Panel	M. tuberculosis	Mycobacterium tuberculosis	1773	4.5 Mb	495	202851
Haemophilus Influenzae Panel	H. influenzae	Haemophilus influenzae	727	1.9 Mb	119	193690
Streptococcus Pyogenes Panel	Group A Streptococcus	Streptococcus pyogenes	1314	1.7 Mb	305	123724
Klebsiella Pneumoniae Panel	K. pneumoniae	Klebsiella pneumoniae	573	5.7 Mb	15220	1195288
Acinetobacter Baumannii Panel	A. baumannii	Acinetobacter baumannii	470	4 Mb	2177	600247
Streptococcus Pneumoniae Panel	S. pneumoniae	Streptococcus pneumoniae	1313	2.1 Mb	247	154689

PERFORMANCE

Performance — Measured Results

Selected measured metrics and coverage demonstration for representative pathogens (figures from internal validation).

Influenza virus

SARS‑CoV‑2

Parainfluenza virus

Respiratory syncytial virus

Human metapneumovirus

Adenovirus

Mycoplasma pneumoniae

Bordetella pertussis

ORDERING INFO

Ordering Information — Catalog & Pack Sizes

Available pack sizes and catalog numbers for each panel.

Panel	16 rxn	96 rxn
Influenza A/B/C Virus Panel	PH2000051	PH2000052
SARS-CoV-2 Panel	PH2001721	PH2001722
Pathogenic Coronavirus Panel	PH2001541	PH2001542
Human Respiratory Syncytial Virus Panel	PH2000701	PH2000702
Human Metapneumovirus Panel	PH2001131	PH2001132
Human Parainfluenza Virus Panel	PH2001381	PH2001382
Human Mastadenovirus Panel	PH2001061	PH2001062
Rhinovirus Panel	PH2001881	PH2001882
Varicella-Zoster Virus Panel	PH2004171	PH2004172
Mycoplasma Pneumoniae Panel	PH2000031	PH2000032
Chlamydia Psittaci Panel	PH2002161	PH2002162
Chlamydia Pneumoniae Panel	PH2005771	PH2005772
Chlamydia Trachomatis Panel	PH2006071	PH2006072
Bordetella Pertussis Panel	PH2001121	PH2001122
Mycobacterium Tuberculosis Panel	PH2001181	PH2001182
Haemophilus Influenzae Panel	PH2003791	PH2003792
Streptococcus Pyogenes Panel	PH2003471	PH2003472
Klebsiella Pneumoniae Panel	PH2003601	PH2003602
Acinetobacter Baumannii Panel	PH2003581	PH2003582
Streptococcus Pneumoniae Panel	PH2003591	PH2003592

KEY ADVANTAGES

Why Choose OmniCapture Respiratory Panel

Industry-leading technology for respiratory pathogen detection

Comprehensive Coverage

Detects over 50 respiratory pathogens in a single test, reducing the need for multiple assays

Full-Genome Capture

Complete genome sequencing enables variant detection and strain typing

High Sensitivity

Detects low-level pathogens with high enrichment efficiency

Co-Infection Detection

Identifies multiple pathogens simultaneously, including co-infections

Standardized Workflow

Compatible with automated platforms for consistent results

Regulatory Ready

Designed to meet clinical testing requirements and quality standards

REFERENCES

References

Key publications and validation references.

Yu F, Ma N, Zhang X, et al. Comprehensive investigating of cytokine and receptor related genes variants in patients with chronic hepatitis B virus infection. Cytokine. 2018 Mar;103:10-14.
Pang X, Ren L, et al. Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing. Natl Sci Rev. 2020 Oct 23;7(12):1861-1864.
Du P, Ding N, et al. Genomic surveillance of COVID-19 cases in Beijing. Nat Commun. 2020 Oct 30;11(1):5503.
Chen C, Li J, et al. MINERVA: A Facile Strategy for SARS-CoV-2 Whole-Genome Deep Sequencing of Clinical Samples. Mol Cell. 2020 Dec 17;80(6):1123-1134.e4.
Xu Y, Kang L, et al. Dynamics of severe acute respiratory syndrome coronavirus 2 genome variants in the feces during convalescence. J Genet Genomics. 2020 Oct 20;47(10):610-617.
Wu X, Ning C, et al. A 3,000-year-old, basal S. enterica lineage from Bronze Age Xinjiang suggests spread along the Proto-Silk Road. PLoS Pathog. 2021 Sep 21;17(9):e1009886.
Zhang J, Ding N, et al. Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak. Innovation (Camb). 2021 May 28;2(2):100099.
Li J, Du P, et al. Two-step fitness selection for intra-host variations in SARS-CoV-2. Cell Rep. 2022 Jan 11;38(2):110205.
Song S, Li C, et al. Genomic Epidemiology of SARS-CoV-2 in Pakistan. Genomics Proteomics Bioinformatics. 2021 Oct;19(5):727-740.
Zhang J, Tian X, et al. Feasibility and Accuracy of Menstrual Blood Testing for High-risk Human Papillomavirus Detection With Capture Sequencing. JAMA Netw Open. 2021 Dec 1;4(12):e2140644.
Li P, Ke Y, et al. Targeted screening of genetic associations with COVID-19 susceptibility and severity. Front Genet. 2022 Nov 30;13:1073880.
Pu R, Liu W, et al. The Effects and Underlying Mechanisms of Hepatitis B Virus X Gene Mutants on the Development of Hepatocellular Carcinoma. Front Oncol. 2022 Feb 10;12:836517.
Zhang M, Zhang H, et al. Liver biopsy of chronic hepatitis B patients indicates HBV integration profile may complicate the endpoint and effect of entecavir treatment. Antiviral Res. 2022 Aug;204:105363.
Shen C, Li Y, et al. HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation. Nat Commun. 2022 Nov 30;13(1):7368.
Liu W, Cai S, et al. HBV preS Mutations Promote Hepatocarcinogenesis by Inducing Endoplasmic Reticulum Stress and Upregulating Inflammatory Signaling. Cancers (Basel). 2022 Jul 4;14(13):3274.
Wang Y, Nan X, et al. Consumption of Supplementary Inulin Modulates Milk Microbiota and Metabolites in Dairy Cows with Subclinical Mastitis. Appl Environ Microbiol. 2022 Feb 22;88(4):e0205921.
Lang B, Cao C, et al. Genomic alterations related to HPV infection status in a cohort of Chinese prostate cancer patients. Eur J Med Res. 2023 Jul 17;28(1):239.
Adeola AC, Luka PD, et al. Target capture sequencing for the first Nigerian genotype I ASFV genome. Microb Genom. 2023 Jul;9(7):mgen001069.
Sun B, Andrades Valtueña A, et al. Origin and dispersal history of Hepatitis B virus in Eastern Eurasia. Nat Commun. 2024 Apr 5;15(1):2951.
Wang Z, Liu C, et al. Long-read sequencing reveals the structural complexity of genomic integration of HPV DNA in cervical cancer cell lines. BMC Genomics. 2024 Feb 20;25(1):198.
Yang Z, Zeng J, et al. Detection of HBV DNA integration in plasma cell-free DNA of different HBV diseases utilizing DNA capture strategy. Virol Sin. 2024 Aug;39(4):655-666.