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Immunodeficiency Related Pathogens Panel

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IMMUNE PATHOGEN CONTEXT

Immune-Targeting Pathogens

Immune-related pathogens (immune-targeting pathogens) directly infect or destroy host immune cells or disrupt immune regulatory pathways, which can trigger immune dysregulation, deficiency, or hyperactivation. They spread through blood, body fluids, mucosa, or cell-to-cell contact, causing acute infections as well as chronic or latent infections that raise the risk of opportunistic infections, malignancies, and autoimmune diseases.

iGeneTech combines proprietary TargetSeq® liquid-phase probe hybrid capture technology with bespoke microbial probe design to solve critical challenges such as viral mutation surveillance, low-abundance virus detection, and host tracing, and now offers multiple whole-genome kits for immune-related pathogens.

COMPREHENSIVE IMMUNODEFICIENCY PATHOGENS

Comprehensive Immunodeficiency Pathogen Detection Panels

This curated set of capture panels targets high-priority immune-related pathogens with transparent reference metrics so laboratories can quickly gauge what data underlies each panel.

Product Name English Name Taxonomy ID Reference Genome Size Reference Sequence Number Number Of Probes
Monkeypox Virus Panel Monkeypox virus 10244 196.9 kb 2442 40002
HIV Panel Human immunodeficiency virus 1 11676 9.2 kb 34815 265045
Human immunodeficiency virus 2 11709 10.4 kb
Cytomegalovirus Panel Cytomegalovirus 10358 235.6 kb 422 130424
Ebola Virus & Marburg Virus Panel Ebola virus 1570291 19 kb 108 8543
Marburg virus 33727 19.1 kb 4
MEASURED PERFORMANCE

Measured Performance

Real-world capture performance highlights for select immunodeficiency-related targets.

Monkeypox virus coverage metrics
HIV panel coverage
CATALOG NUMBERS & KIT SIZES

Catalog Numbers & Kit Sizes

Available catalog SKUs for the performance-highlighted panels.

Product Name 16 rxn 96 rxn Order
Monkeypox Virus Panel PH2002641 PH2002642
HIV Panel PH2015081 PH2015082
Cytomegalovirus Panel PH2012941 PH2012942
Ebola Virus & Marburg Virus Panel PH2012951 PH2012952
PANEL OVERVIEW

Comprehensive Opportunistic Pathogen Detection

The Immunodeficiency Related Pathogens Panel enables simultaneous detection and identification of over 80 opportunistic pathogens from a single sample, specifically designed for immunocompromised patients at high risk for severe infections.

Immunocompromised Focus

Targets pathogens that pose significant risk to transplant, oncology, and HIV/AIDS patients

Broad Pathogen Coverage

Detects viruses, bacteria, fungi, and parasites commonly causing opportunistic infections

Full-Genome Analysis

Complete genome capture enables drug resistance mutation detection and strain typing

Rapid Results

Streamlined workflow delivers results within 24-48 hours for timely intervention

REFERENCES

References

Key literature supporting the performance and applications of targeted pathogen capture sequencing.

  1. Yu F, Ma N, Zhang X, et al. Comprehensive investigation of cytokine and receptor related gene variants in patients with chronic hepatitis B virus infection. Cytokine. 2018 Mar;103:10-14.
  2. Pang X, Ren L, et al. Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing. Natl Sci Rev. 2020 Oct 23;7(12):1861-1864.
  3. Du P, Ding N, et al. Genomic surveillance of COVID-19 cases in Beijing. Nat Commun. 2020 Oct 30;11(1):5503.
  4. Chen C, Li J, et al. MINERVA: A Facile Strategy for SARS-CoV-2 Whole-Genome Deep Sequencing of Clinical Samples. Mol Cell. 2020 Dec 17;80(6):1123-1134.e4.
  5. Xu Y, Kang L, et al. Dynamics of severe acute respiratory syndrome coronavirus 2 genome variants in the feces during convalescence. J Genet Genomics. 2020 Oct 20;47(10):610-617.
  6. Wu X, Ning C, et al. A 3,000-year-old, basal S. enterica lineage from Bronze Age Xinjiang suggests spread along the Proto-Silk Road. PLoS Pathog. 2021 Sep 21;17(9):e1009886.
  7. Zhang J, Ding N, et al. Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak. Innovation (Camb). 2021 May 28;2(2):100099.
  8. Li J, Du P, et al. Two-step fitness selection for intra-host variations in SARS-CoV-2. Cell Rep. 2022 Jan 11;38(2):110205.
  9. Song S, Li C, et al. Genomic Epidemiology of SARS-CoV-2 in Pakistan. Genomics Proteomics Bioinformatics. 2021 Oct;19(5):727-740.
  10. Zhang J, Tian X, et al. Feasibility and Accuracy of Menstrual Blood Testing for High-risk Human Papillomavirus Detection With Capture Sequencing. JAMA Netw Open. 2021 Dec 1;4(12):e2140644.
  11. Li P, Ke Y, et al. Targeted screening of genetic associations with COVID-19 susceptibility and severity. Front Genet. 2022 Nov 30;13:1073880.
  12. Pu R, Liu W, et al. The Effects and Underlying Mechanisms of Hepatitis B Virus X Gene Mutants on the Development of Hepatocellular Carcinoma. Front Oncol. 2022 Feb 10;12:836517.
  13. Zhang M, Zhang H, et al. Liver biopsy of chronic hepatitis B patients indicates HBV integration profile may complicate the endpoint and effect of entecavir treatment. Antiviral Res. 2022 Aug;204:105363.
  14. Shen C, Li Y, et al. HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation. Nat Commun. 2022 Nov 30;13(1):7368.
  15. Liu W, Cai S, et al. HBV preS Mutations Promote Hepatocarcinogenesis by Inducing Endoplasmic Reticulum Stress and Upregulating Inflammatory Signaling. Cancers (Basel). 2022 Jul 4;14(13):3274.
  16. Feng XL, Yu D, et al. Characteristics of replication and pathogenicity of SARS-CoV-2 Alpha and Delta isolates. Virol Sin. 2022 Dec;37(6):804-812.
  17. Wang Y, Nan X, et al. Consumption of Supplementary Inulin Modulates Milk Microbiota and Metabolites in Dairy Cows with Subclinical Mastitis. Appl Environ Microbiol. 2022 Feb 22;88(4):e0205921.
  18. Lang B, Cao C, et al. Genomic alterations related to HPV infection status in a cohort of Chinese prostate cancer patients. Eur J Med Res. 2023 Jul 17;28(1):239.
  19. Adeola AC, Luka PD, et al. Target capture sequencing for the first Nigerian genotype I ASFV genome. Microb Genom. 2023 Jul;9(7):mgen001069.
  20. Sun B, Andrades Valtueña A, et al. Origin and dispersal history of Hepatitis B virus in Eastern Eurasia. Nat Commun. 2024 Apr 5;15(1):2951.
  21. Wang Z, Liu C, et al. Long-read sequencing reveals the structural complexity of genomic integration of HPV DNA in cervical cancer cell lines. BMC Genomics. 2024 Feb 20;25(1):198.
  22. Yang Z, Zeng J, et al. Detection of HBV DNA integration in plasma cell-free DNA of different HBV diseases utilizing DNA capture strategy. Virol Sin. 2024 Aug;39(4):655-666.

Ready to Enhance Your Immunodeficiency Testing?

Contact our team to learn more about the Immunodeficiency Related Pathogens Panel and how it can benefit your laboratory or clinical facility.

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